After I helped Max in the sewers (when they are infested with slime) and finished the quest on the alchemy table, I couldn’t access the inventory or the game menu using the controller or keyboard. The issue continued through the boss fight and I couldn’t pause the game. After I died in the boss encounter, everything was back to normal. Also a black line appeared for a second once entering combat, but this to stopped happening after i died.
This is the only “major” bug I’ve encountered during some 10 hours of game play.